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Iodine (125I) CC49 : ウィキペディア英語版 | Iodine (125I) CC49
Iodine (125I) CC49 is an iodine-125 radiolabelled monoclonal antibody for the detection of tumours. It is used in radioimmunoassays such as CA 72-4. CC49 has also been tested for the treatment of solid tumours, but without success. Iodine (131I) CC49 and lutetium (177Lu) CC49, for example, were shown to induce human anti-mouse antibodies; no tumour response was observed in Phase I and II clinical trials. == Derivatives == A wide range of CC49 derivatives has been used in pharmaceutical research. Examples include chimeric〔 and humanized CC49, as well as a fusion protein of a CC49 single-chain variable fragment and the enzyme beta-lactamase.
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